Scientific articles

Selected scientific articles authored by Dr Holm, 

see the entire publication list here

Obesity related complications in children and adolescents

27% exhibit dyslipidemia (Appendix 1)

31% exhibit liver and 66% exhibit muscle steatosis (Appendix 2, Appendix 3, Appendix 4, and Appendix 5)

50% exhibit pre- or overt hypertension (Appendix 6 and Appendix 7)

10,4% exhibit subclinical hypothyroidism (Appendix 8)

16,5% exhibit vitamin D deficiency (Appendix 9)

Treatment in the primary sector with the following effects:

74% of patients exhibit weight loss (Appendix 10)

Improvement of quality of life (Appendix 11)

Reduction in blood pressure (Appendix 12)

Treatment in the secondary sector with the following effects:

69% and 75% exhibit weight loss (Appendix 13 and Appendix 14)

Reduction in cholesterol levels (Appendix 15)

Reduction in blood pressure (Appendix 16 and Appendix 17)

Reduction of fatty liver and muscle fat (Appendix 18)

Improvement of quality of life (Appendix 19)

Weight loss in parents (Appendix 20)

Improvements in 9 out of 10 in cholesterol levels/degree of obesity/body composition (Appendix 21)

Equally effective treatment response despite familiar predispositions to obesity related comorbidities (Appendix 22)

Equally effective treatment response despite impaired glucose metabolism (Appendix 23)

Equally effective treatment response despite a genetic risk score composed of 15 commonly occurring with impact on development of obesity in children and youth (Appendix 24)

Same obesity treatment aproach regardless of disturbed eating behavior (Appendix 24a)

Danish recommendations based on this method (Appendix 25a)

International recommendations for the treatment of youth with obesity (Appendix 25b)

Medication to children and adolescents with obesity

Patients with MC4R mutations are more difficult to treat (Appendix 26a)

Patients with MC4R mutations can be treated with medicine (Appendix 26)

Inconsistencies in dosage of medication in children and youth with obesity (Appendix 27)​

Genetic aspects of childhood obesity

Identification of 3 new genes with impact on obesity in children and youth (Appendix 28)

Genetic risk score describing insulin sensitivity, metabolic disease and altered fat distribution (Appendix 29)

Genetics and thyroid hormones (Appendix 30)

Genetics, birth weight and cardiovascular disease later in life (Appendix 31)

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors (Appendix 32)

2 new genes (Appendix 32a)

Pregnancy and early growth

Affected birth weight and length of pregnancy (Appendix 33)

Obesity related markers of gestational diabetes (Appendix 34)

Association between birth weight, degree of obesity, and body composition (Appendix 35 and Appendix 36)

Other effects of childhood obesity

The gut microbiome can induce obesity (Appendix 37)

Physical activity in children and adolescents with obesity (Appendix 38)

Investigation of sensory-specific satiety (Appendix 39)

Markers of childhood obesity

Reference values for markers of obesity and comorbidities (Appendix 40, Appendix 41, and Appendix 42)

Changes in markers of obesity and comorbidities following obesity treatment (Appendix 43, Appendix 44, Appendix 45, and Appendix 46).

Relation between high blood glucose and comorbidities (Appendix 47 and Appendix 48)

Regarding obesity as a chronic disease and the lack of available treatment options

Position statement for declaring obesity as a chronic disease in Europe (Appendix 49)

Lack of available treatment clinics in Denmark (Appendix 50)​​

Proposal for new diagnostic criteria for obesity (Appendix 51)

Treatment and ethics

The ethics in childhood obesity treatment (Appendix 52)

COVID-19

Obesity and COVID-19 from The European Association (Appendix 53)

Obesity, COVID-19 and the immune system from The European Association (Appendix 54)

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